获得您需要的灵敏度和速度,可以对更多样品进行快速检测,并通过高内涵筛选分析获取更多参数。 我们的高内涵筛选分析系统可帮助您回答错综复杂的生物学问题,凭借功能强大且界面友好的成像和分析功能,该系统可灵活应用于从基础科研到实验模型开发以及药物筛选的一系列应用 -这些功能强大的高内涵显微镜系统为您提供了前所未有的高内涵筛选图像质量, 结合PerkinElmer的自动化系统和强大高级数据分析解决方案, 该体系将快速助力您的科研工作更上一层楼。 仅系统仅供研究使用。 不用于诊断程序。

Business Insights (6)

1-6 的 6 Business Insights

  • 应用文献

    Imaging Bile Canaliculi in 3D Liver Microtissues using the Opera Phenix HCS System

    Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated with an increased risk of cholestatic liver injury. Here, we describe a 3D high-content screening assay to study hepatobiliary transporter function in InSphero human liver microtissues. Confocal imaging and automated image analysis were used to quantify BSEP and MRP-2-mediated efflux of fluorescent substrates into bile canaliculi.

  • 应用文献

    Phenotypic Analysis of Hypertrophy in Human iPSC-Derived Cardiomyocytes

    Learn how a phenotypic screening assay to study time-dependent effects of endothelin-1-induced hypertrophy was set up using human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Learn how: The Opera Phenix system has been applied in the field of neurodegenerative diseases. In this assay, the Opera Phenix system is 4 times faster than the previous Opera® system. Primary neuron morphology is analyzed in a straightforward approach using Harmony software. Careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.

  • 应用文献

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS™ high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony® software contribute to the robustness of the high-content assay.

  • 应用文献

    Phenotypic Profiling of Autophagy using the Opera Phenix High-Content Screening System

    Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • 应用文献



  • 案例分析

    High-Content Analysis of Drug-Induced Oligodendrocyte Differentiation Promoting Remyelination in Multiple Sclerosis

    One of the greatest challenges in multiple sclerosis (MS) therapy is the halting or reversal of the failure of remyelination in the brain in order to reverse disabilities in MS patients. This case study highlights the recent work of Dr. Paul Tesar and colleagues at the Case Western Reserve University School of Medicine, which could potentially lead to such novel treatments, as it aims to control the function of stem cells in the body and thereby to help the body repair itself.

产品与服务 (3)

1-3 的 3 产品与服务

  • 1000x1000_Operetta

    Operetta CLS 高内涵系统

    Operetta CLS™ 系统帮助您探索常规实验与复杂创新实验中的生物学信息。通过一系列创新技术的有机结合,Operetta CLS™ 同时满足精细细胞细节成像对高速、高灵敏度、高分辨率检测多方面的需求。同时,凭借功能强大的Harmony 4.5版软件,Operetta CLS™ 可帮助您手机版并定量细微的细胞表型改变。
  • Operetta FrontAngle green copy

    Operetta 高内涵系统

    随着科学家对于复杂生物问题探讨的日益加深,研究者对于大规模复杂的生物学模型的需求要越来越广泛。所以他们选择了Operetta CLS® 高内涵筛选系统-对于健康或疾病细胞内部机制研究的理想工具。
  • 1000x1000_Opera_Phenix

    Opera Phenix 高内涵系统

    Opera Phenix™高内涵系统是目前最受期待的高内涵共聚焦技术方案。依赖将近20年的顶尖高内涵产品opera高内涵成像系统积累的丰富成像和应用经验,新一代的opera phenix系统系统专为高内涵表型筛选以及复杂的疾病模型量身打造,例如活细胞、原代细胞,细胞微组织。