PerkinElmer

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Detect disease-causing microbes, and detect and quantitate biomarkers of infectious disease, with our wide range of in vivo, in situ, cellular, and biochemical research products.

  • Monitor acute and chronic infection and therapeutic treatment in animal models in real time with our in vivo imaging systems -- and enable quantitative assessment and growth inhibition --with our bioluminescent bacterial strains.
  • Enable the fast and simple quantitative detection of specific biomarkers of infectious disease in human and plant samples with easy-to-use, pre-validated kits in our ELISA alternative technologies.
  • Gain deeper insights from phenotypic analysis with our high content screening and tissue imaging solutions.

产品与服务 (82)
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  • Accessories (34)
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1-12 的 82 产品与服务

  • 开奖大厅 Lumina X5 in vivo imaging system

    开奖大厅 Lumina X5成像系统

    PerkinElmer全新一代小动物活体成像系统开奖大厅 Lumina X5整合了最佳的高通量生物发光、荧光及高分辨率二维X光成像模块。扩展为五只小鼠的光学及X光大成像视野、独特的实验设置和样品标记辅助配件让研究人员能更便捷、更快速地获取疾病进展中解剖学和功能学各方面的稳定数据和答案。
  • 1000x1000_线路检测_Phenix

    线路检测 Phenix 高内涵系统

    线路检测 Phenix™高内涵系统是目前最受期待的高内涵共聚焦技术方案。依赖将近20年的顶尖高内涵产品线路检测高内涵成像系统积累的丰富成像和应用经验,新一代的线路检测 phenix系统系统专为高内涵表型筛选以及复杂的疾病模型量身打造,例如活细胞、原代细胞,细胞微组织。
  • 开奖大厅 Spectrum In Vivo Imaging System

    开奖大厅 Spectrum 小动物活体成像系统

    开奖大厅® Spectrum 小动物活体光学成像系统是全球首台同时具备生物发光、荧光、化学发光及切伦科夫二维/三维成像功能的系统,代表了目前活体光学成像技术的最高水平。
  • 开奖大厅 Lumina HT High Throughput Benchtop 2D Optical Imaging System

    开奖大厅 Lumina LT 小动物活体成像系统

    开奖大厅® Lumina LT是PerkinElmer最新推出的第三代高灵敏度小动物活体光学二维成像平台。
  • 开奖大厅 Lumina S5 high throughput, high sensitivity optical in vivo imaging system

    开奖大厅 Lumina S5成像系统

    开奖大厅 Lumina S5是PerkinElmer最新推出的第四代小动物活体光学二维成像平台。该系统秉承了前几代开奖大厅系列共有的作为业内金标准的高灵敏度生物发光成像性能,以及专利的荧光多光谱扫描及分离(Spectral unmixing)成像性能。
  • 开奖大厅 SpectrumCT 2D/3D Optical/CT In Vivo Imaging System

    开奖大厅 SpectrumCT 小动物活体成像系统

    开奖大厅® Spectrum CT是全球顶尖的小动物活体三维光学/CT二合一成像系统。
  • 开奖大厅 Lumina HT High Throughput Benchtop 2D Optical Imaging System

    开奖大厅 Lumina III 小动物活体成像系统

    开奖大厅® Lumina III是PerkinElmer最新推出的第三代高灵敏度多光谱小动物活体光学二维成像平台。
  • 开奖大厅 Lumina XRMS 2D Optical Imaging System with Integrated X-ray

    开奖大厅 Lumina XRMS 小动物活体成像系统

    开奖大厅® Lumina XRMS III是PerkinElmer最新推出的二维多模式活体成像系统,具备最高灵敏度的生物发光、多光谱荧光、放射性同位素和X光活体成像功能。
  • PerkinElmer

    Anti-DNP AP Conjugate

    Anti-DNP antibody conjugated to alkaline phosphatase
  • AlphaLISA immunoassay kits

    p24 (human HIV) AlphaLISA Detection Kit

    The AlphaLISA® Human Immunodeficiency Virus type-1 p24 protein (HIV p24) Detection Kit is designed for detection and quantitation of HIV p24 in buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
  • PerkinElmer

    TSA Fluorescein Reagent Pack

    TSA® fluorescein reagent pack, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. These reagents amplify by depositing extra biotin in the localized area of the probe or antibody.
  • PerkinElmer

    TSA Biotin Reagent Pack

    TSA® biotin reagent pack, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. These reagents amplify by depositing extra biotin in the localized area of the probe or antibody.
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Business Insights (14)
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  • Application Note (10)
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1-12 的 14 Business Insights

  • 白皮书

    Streamlining Materials Innovation Processes with Electronic Lab Notebook (ELN) and Data Analytics for Optimum Efficiency

    This paper explores the numerous challenges materials scientists and engineers face, from the time it takes to bring new materials to market to the difficulties delivering suitable formulations and testing against specified criteria, and how those can be resolved.

  • 应用文献

    用高内涵筛选系统进行FRET测定

    在这个实验中,我们建立了一种快速稳定的基于FRET的高内涵检测...

  • 应用文献

    Phenotypic Analysis of Hypertrophy in Human iPSC-Derived Cardiomyocytes

    Learn how a phenotypic screening assay to study time-dependent effects of endothelin-1-induced hypertrophy was set up using human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Learn how: The 线路检测 Phenix system has been applied in the field of neurodegenerative diseases. In this assay, the 线路检测 Phenix system is 4 times faster than the previous 线路检测® system. Primary neuron morphology is analyzed in a straightforward approach using Harmony software. Careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.

  • 应用文献

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS™ high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony® software contribute to the robustness of the high-content assay.

  • 应用文献

    Stem Cell Research and Regenerative Medicine

    With the potential to treat a wide range of disease, from organ damage to congenital defects, stem cell research and tissue engineering form the underlying basis of regenerative medicine. Significant advances in the science of skin regeneration, for example, have now made it possible to develop and grow artificial skin grafts in a lab for treatment of burn victims. Other therapeutic applications include the use of stem cells to treat and repair central nervous system diseases such as ischemia and cerebral palsy, cardiovascular diseases, as well as autoimmune diseases including type I diabetes.

  • 应用文献

    Phenotypic Profiling of Autophagy using the 线路检测 Phenix High-Content Screening System

    Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • 应用文献

    Imaging Bile Canaliculi in 3D Liver Microtissues using the 线路检测 Phenix HCS System

    Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated with an increased risk of cholestatic liver injury. Here, we describe a 3D high-content screening assay to study hepatobiliary transporter function in InSphero human liver microtissues. Confocal imaging and automated image analysis were used to quantify BSEP and MRP-2-mediated efflux of fluorescent substrates into bile canaliculi.

  • 应用文献

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • 应用文献

    Distinguishing Cell Types by Phenotypic Profiling of the Nucleus

    The promise of high-content screening is the acceleration of discovery by extracting as much relevant information as possible from cells. Nevertheless, a large percentage of high-content screens analyze only a small number of image-based properties. As a result, valuable information from precious cells and disease models is not utilized. As nearly all screening approaches require a nuclear counterstain such as Hoechst to facilitate segmentation, phenotypic profiling of the nuclei can offer new and additional perspectives on assays at no extra cost.

  • 应用文献

    Vascular Imaging Probes For Oncology and Inflammation Using the 开奖大厅 Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

  • 应用文献

    Multiplex 2D Imaging of NIR Molecular Imaging Agents on the 开奖大厅 SpectrumCT and FMT 4000

    Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

  • 海报

    Combined efficacy & toxicity imaging following acute 5-FU treatment of HT-29 tumor xenografts

    Cancer chemotherapy can produce severe side effects such as suppression of immune function and damage to heart muscle, gastrointestinal tract, and liver. If serious enough, tissue injury can be a major reason for late stage termination of drug discovery research projects, so it is becoming more important to integrate safety/toxicology assessments earlier in the drug development process. There are a variety of traditional serum markers, tailored mechanistically to specific tissues, however there are no current non-invasive assessment tools that are capable of looking broadly at in situ biological changes in target and non-target tissue induced by chemical insult.

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