PerkinElmer

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Engineer drug candidates with the lowest risk of failure in the critical latter stages of drug development. Our lead optimization solutions reduce off-target activity through improved selectivity, enhance potency, and improve the chemical and metabolic properties of the lead compound for better in vivo pharmacodynamics and pharmacokinetics.

We also offer informatics software applications that help you manage chemical structures and their associated data and properties in an efficient and chemically intelligent way.

产品与服务 (119)
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检测方法
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  • 开奖大厅 (30)
  • 开奖大厅 CLS AND 线路检测 Phenix (10)
  • 开奖大厅 CLS (8)
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1-12 的 119 产品与服务

  • 1000x1000_开奖大厅

    开奖大厅 CLS 高内涵系统

    开奖大厅 CLS™ 系统帮助您探索常规实验与复杂创新实验中的生物学信息。通过一系列创新技术的有机结合,开奖大厅 CLS™ 同时满足精细细胞细节成像对高速、高灵敏度、高分辨率检测多方面的需求。同时,凭借功能强大的Harmony 4.5版软件,开奖大厅 CLS™ 可帮助您手机版并定量细微的细胞表型改变。
  • 1000x1000_线路检测_Phenix

    线路检测 Phenix 高内涵系统

    线路检测 Phenix™高内涵系统是目前最受期待的高内涵共聚焦技术方案。依赖将近20年的顶尖高内涵产品线路检测高内涵成像系统积累的丰富成像和应用经验,新一代的线路检测 phenix系统系统专为高内涵表型筛选以及复杂的疾病模型量身打造,例如活细胞、原代细胞,细胞微组织。
  • FMT In Vivo Imaging Instrument

    FMT 1000 In Vivo Imaging System

    The FMT® 1000 is an entry level 3D fluorescence tomographic system with the ability to quantitate a single fluorophore at a time.
  • 手机预测 Spectrum In Vivo Imaging System

    手机预测 Spectrum 小动物活体成像系统

    手机预测® Spectrum 小动物活体光学成像系统是全球首台同时具备生物发光、荧光、化学发光及切伦科夫二维/三维成像功能的系统,代表了目前活体光学成像技术的最高水平。
  • 手机预测 Lumina HT High Throughput Benchtop 2D Optical Imaging System

    手机预测 Lumina LT 小动物活体成像系统

    手机预测® Lumina LT是PerkinElmer最新推出的第三代高灵敏度小动物活体光学二维成像平台。
  • 免费试玩 X_ImageA_320px

    免费试玩 多模式读板仪

    新一代的 免费试玩 X 系列多模式读板仪为各种规模的实验室提供集灵活性、高速度和高性能于一体的解决方案。
  • 开奖号码 Multimode Plate Reader

    开奖号码 多模式读板仪

    开奖号码 多模式读板仪是一台整合了多标记、无标记和显微成像技术的桌面式一体化检测平台。其整孔成像&在线数据分析速度非常快,可以在五分钟内完成384孔板整板的图像获取及分析。该仪器采用预置模块化设计,结合基于Kaleido软件的数据采集和分析流程,是一台真正的全能且高产的多模式读板仪。
  • 手机预测 SpectrumCT 2D/3D Optical/CT In Vivo Imaging System

    手机预测 SpectrumCT 小动物活体成像系统

    手机预测® Spectrum CT是全球顶尖的小动物活体三维光学/CT二合一成像系统。
  • 手机预测 Lumina HT High Throughput Benchtop 2D Optical Imaging System

    手机预测 Lumina III 小动物活体成像系统

    手机预测® Lumina III是PerkinElmer最新推出的第三代高灵敏度多光谱小动物活体光学二维成像平台。
  • G8 PET/CT benchtop scanner for preclinical imaging research

    G8 PET/CT 成像系统集

    PerkinElmer 公司最新研发的 G8 PET/CT 二合一成像系统集成了高灵敏度 PET 成像及快速、低剂量 microCT 成像,使研究者在进行功能或代谢研究的同时,获取结构性图像数据。
  • FMT In Vivo Imaging Instrument

    FMT 2000 In Vivo Imaging System

    The FMT 2000 is a workhorse 3D fluorescence tomographic system with the ability to quantitate up to two fluorophores simultaneously.
  • FMT In Vivo Imaging Instrument

    FMT 4000 In Vivo Imaging System

    The FMT 4000 fluorescence tomography imaging system provides the greatest utility of the FMT Systems with the ability to quantitate up to four fluorophores simultaneously. It comes with four excitation laser channels (635, 680, 750, & 790 nm).
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Business Insights (17)
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  • Application Note (12)
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1-12 的 17 Business Insights

  • 白皮书

    Streamlining Materials Innovation Processes with Electronic Lab Notebook (ELN) and Data Analytics for Optimum Efficiency

    This paper explores the numerous challenges materials scientists and engineers face, from the time it takes to bring new materials to market to the difficulties delivering suitable formulations and testing against specified criteria, and how those can be resolved.

  • 应用文献

    用高内涵筛选系统进行FRET测定

    在这个实验中,我们建立了一种快速稳定的基于FRET的高内涵检测...

  • 应用文献

    Preclinical Fluorescence Imaging of Cancer Metastasis to the Lung and Response to Therapy

    Quantitative pre-clinical fluorescence imaging transcends the boundaries of traditional optical imaging of biological structures and physiology by providing information at the molecular level about disease states and therapeutic response. Fluorescent Pre-clinical Imaging Agents and FMT® (Fluorescence Molecular Tomography) Quantitative Pre-clinical Imaging Systems represent powerful tools for research and drug development in the imaging of biological processes and pharmaceutical activity in living animals.

  • 应用文献

    Phenotypic Analysis of Hypertrophy in Human iPSC-Derived Cardiomyocytes

    Learn how a phenotypic screening assay to study time-dependent effects of endothelin-1-induced hypertrophy was set up using human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Learn how: The 线路检测 Phenix system has been applied in the field of neurodegenerative diseases. In this assay, the 线路检测 Phenix system is 4 times faster than the previous 线路检测® system. Primary neuron morphology is analyzed in a straightforward approach using Harmony software. Careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.

  • 应用文献

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the 开奖大厅 CLS™ high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the 开奖大厅 CLS system and the easy-to-use image analysis tools of the Harmony® software contribute to the robustness of the high-content assay.

  • 应用文献

    Stem Cell Research and Regenerative Medicine

    With the potential to treat a wide range of disease, from organ damage to congenital defects, stem cell research and tissue engineering form the underlying basis of regenerative medicine. Significant advances in the science of skin regeneration, for example, have now made it possible to develop and grow artificial skin grafts in a lab for treatment of burn victims. Other therapeutic applications include the use of stem cells to treat and repair central nervous system diseases such as ischemia and cerebral palsy, cardiovascular diseases, as well as autoimmune diseases including type I diabetes.

  • 应用文献

    Phenotypic Profiling of Autophagy using the 线路检测 Phenix High-Content Screening System

    Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • 应用文献

    Imaging Bile Canaliculi in 3D Liver Microtissues using the 线路检测 Phenix HCS System

    Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated with an increased risk of cholestatic liver injury. Here, we describe a 3D high-content screening assay to study hepatobiliary transporter function in InSphero human liver microtissues. Confocal imaging and automated image analysis were used to quantify BSEP and MRP-2-mediated efflux of fluorescent substrates into bile canaliculi.

  • 应用文献

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • 应用文献

    NIR Fluorescent Cell Labeling for In Vivo Cell Tracking (VivoTrack 680)

    Fluorescent dyes have been used for many years to label cells for microscopy studies, and a variety of dyes in the visible fluorescence spectrum are available to label different cellular compartments and organelles. Efficient delivery of the fluorophore to the cell without excessively modifying surface proteins or perturbing cell function is the major biotechnological challenge. In addition, researchers have taken on the challenge of in vivo imaging, focusing on near infrared (NIR) dyes that fluoresce in a spectral region better suited for in vivo imaging due to reduced background and higher tissue penetration.

  • 应用文献

    Distinguishing Cell Types by Phenotypic Profiling of the Nucleus

    The promise of high-content screening is the acceleration of discovery by extracting as much relevant information as possible from cells. Nevertheless, a large percentage of high-content screens analyze only a small number of image-based properties. As a result, valuable information from precious cells and disease models is not utilized. As nearly all screening approaches require a nuclear counterstain such as Hoechst to facilitate segmentation, phenotypic profiling of the nuclei can offer new and additional perspectives on assays at no extra cost.

  • 应用文献

    Vascular Imaging Probes For Oncology and Inflammation Using the 手机预测 Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

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