PerkinElmer

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Study targets of metabolic disease in vitro, in vivo and in situ using our biomarker detection kits, imaging systems and target-specific radiolabeled ligands, carbohydrates, lipids, and steroids.

  • Fast, simple, pre-validated kits for detection and quantitation of biomarkers of metabolic disease
  • Radiolabeled ligands, carbohydrates, lipids and steroids for the targeted binding studies

Business Insights (2)
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1-2 的 2 Business Insights

  • 应用文献

    MicroCT Investigation of Bone Erosion and Deformation in an Osteoarthritic Rat Model

    Osteoarthritis (OA) is the most common form of arthritis and affects a considerable portion of the elderly population. In the U.S., it is estimated that more than 630 million people worldwide have this chronic condition, generally in the knees. OA occurs when the cartilage that cushions the ends of bones within the joints gradually deteriorates, causing synovitis and joint deformation.

    The goal of OA research is to identify new therapeutic strategies that could prevent, reduce, halt progression, or repair the existing damage to the joint. Non-invasive in vivo imaging such as microCT is the standard modality for bone research due to its ability to obtain high-resolution images at an x-ray dose low enough as not to harm the animal. This makes microCT ideal for monitoring disease progression and response to treatments in the same animal over time. However, microCT data visualization and analysis can be cumbersome and time consuming. In this application note, we compared standard microCT software and advanced bone software to investigate bone erosion in an OA rat model.

  • 应用文献

    Contrast-enhanced Imaging of Vasculature and Soft Tissues Using the Quantum GX MicroCT System

    X-ray CT imaging is commonly used for skeletal imaging as bones are densely mineralized tissues with excellent x-ray attenuation properties. In contrast, soft, less dense tissues often prove to be challenging to image due to their lack of sufficient tissue density. Soft tissues such as muscle, blood vessels and internal organs share similar x-ray attenuation characteristics and are not distinguishable under typical CT settings. In order to introduce density that would improve soft tissue contrast, several contrast agents have been developed for use in clinical and preclinical settings. This application note outlines the use of iodine and nanoparticle-based contrast agents for imaging soft tissues and vasculature in various organs using the Quantum GX to gain further insights into disease and therapeutic response.

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1-12 的 136 产品与服务

  • Quantum GX2 microCT imaging system

    Quantum GX2 microCT成像系统

    应用领域涉及骨、肿瘤、心血管和肺部等疾病研究。Quantum GX2 micro CT成像系统模式灵活,兼容离体样本、小鼠、大鼠及兔子等多种物种;具备快速、低剂量的扫描模式,适合对活体动物进行长时程研究;具备高分辨率成像特点,能够对离体样本进行高分辨扫描。 Quantum GX2 microCT卓越的性能让您不仅得到图像,而是更深入的理解疾病模型。
  • PIGF (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human placental growth factor (PIGF) enables the quantitative determination of human PIGF (PGF) in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
  • Adenosine 5 Triphosphate 250 µCi

    Mannitol, D-[1-3H(N)]

    D-mannitol, labeled with tritium at C1. Tritiated manitol is commonly used as an extracellular space marker.
  • AlphaLISA immunoassay kits

    ApoB (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human ApoB enables the quantitative determination of human apolipoprotein B in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
  • AlphaLISA assay principle

    Osteoprotegerin (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for total osteoprotegerin enables the quantitative determination of human osteoprotegerin in human serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
  • AlphaLISA assay principle

    MANF (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human MANF enables the quantitative determination of mesencephalic astrocyte-derived neurotrophic factor (MANF) in human serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
  • Protein

    MANF (human) lyophilized (AlphaLISA)

    Human MANF standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Human MANF Detection Kit, but can be ordered separately.
  • AlphaLISA immunoassay kits

    Heme oxygenase 1 AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human heme oxygenase 1 (HO-1) enables the quantitative determination of human HO-1 in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
  • Diclofenac sodium- Phenylacetic acid C14

    Glucosamine, N-Acetyl-D - [1-14C]

    50 µCi quantities of N-Acetyl-D-[1-14C]-Glucosamine are available for your research.
  • AlphaLISA assay principle

    Ghrelin (active) (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for active human ghrelin enables the quantitative determination of active ghrelin in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
  • LANCE Detection Kit

    Glucagon (human) LANCE Ultra TR-FRET Detection Kit

    The LANCE® Ultra Human Glucagon Detection Kit is designed for detection and quantitation of human glucagon in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
  • ApoA1 (human) LANCE Ultra TR-FRET Detection Kit

    The LANCE® Ultra Human ApoA1 Detection Kit is designed for detection and quantitation of human Apolipoprotein A1 (ApoA1) in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
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